TY  - JOUR
AU  - Salmón, Marina
AU  - Paniagua, Guillem
AU  - Fernández-García, Fernando
AU  - Zarzuela, Eduardo
AU  - Álvarez-Díaz, Ruth
AU  - Musteanu, Mónica
AU  - Muñoz, Javier
AU  - Drosten, Matthias
AU  - Lechuga, Carmen G
AU  - Guerra, Carmen
AU  - Caleiras, E
AU  - Ortega Jimenez, Sagrario
AU  - Barbacid, Mariano
PY  - 2021
DO  - 10.1073/pnas.2023112118
UR  - http://hdl.handle.net/20.500.12105/14703
AB  - In mammals, the KRAS locus encodes two protein isoforms, KRAS4A and KRAS4B, which differ only in their C terminus via alternative splicing of distinct fourth exons. Previous studies have shown that whereas KRAS expression is essential for mouse...
LA  - eng
PB  - Nature Publishing Group
KW  - K-RAS 4A
KW  - SPLICE VARIANT
KW  - H-RAS
KW  - MOUSE
KW  - SPECIFICITY
KW  - ONCOGENES
KW  - CANCER
KW  - 4B
KW  - Adenocarcinoma of Lung
KW  - Animals
KW  - Apoptosis
KW  - Cell Proliferation
KW  - Female
KW  - Humans
KW  - Lung Neoplasms
KW  - Male
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Mice, Knockout
KW  - Mutation
KW  - Protein Isoforms
KW  - Proto-Oncogene Proteins p21(ras)
KW  - Tumor Cells, Cultured
KW  - Xenograft Model Antitumor Assays
TI  - KRAS4A induces metastatic lung adenocarcinomas in vivo in the absence of the KRAS4B isoform.
TY  - journal article
ER  -