TY  - JOUR
AU  - Oller, Jorge
AU  - Mendez-Barbero, Nerea
AU  - Ruiz, E Josue
AU  - Villahoz, Silvia
AU  - Renard, Marjolijn
AU  - Canelas, Lizet I
AU  - Briones, Ana M
AU  - Alberca, Rut
AU  - Lozano-Vidal, Noelia
AU  - Hurlé, María A
AU  - Milewicz, Dianna
AU  - Evangelista, Arturo
AU  - Salaices, Mercedes
AU  - Nistal, J Francisco
AU  - Jimenez-Borreguero, Luis J.
AU  - De Backer, Julie
AU  - Campanero, Miguel R
AU  - Redondo, Juan Miguel
PY  - 2017
DO  - 10.1038/nm.4266
SN  - 1078-8956
UR  - http://hdl.handle.net/20.500.12105/6924
AB  - Heritable thoracic aortic aneurysms and dissections (TAAD), including Marfan syndrome (MFS), currently lack a cure, and causative mutations have been identified for only a fraction of affected families. Here we identify the metalloproteinase ADAMTS1...
LA  - eng
PB  - Nature Publishing Group
KW  - ADAMTS1 Protein
KW  - Adult
KW  - Aged
KW  - Aneurysm, Dissecting
KW  - Animals
KW  - Aorta
KW  - Aortic Aneurysm
KW  - Aortic Aneurysm, Thoracic
KW  - Disease Models, Animal
KW  - Enzyme Inhibitors
KW  - Female
KW  - Fibrillin-1
KW  - Gene Knockdown Techniques
KW  - Haploinsufficiency
KW  - Humans
KW  - Immunoblotting
KW  - Male
KW  - Marfan Syndrome
KW  - Mice
KW  - Middle Aged
KW  - NG-Nitroarginine Methyl Ester
KW  - Nitric Oxide
KW  - Nitric Oxide Synthase Type II
KW  - Real-Time Polymerase Chain Reaction
TI  - Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome
TY  - journal article
ER  -