TY  - GEN
AU  - Navas, Carolina
AU  - Hernández-Porras, Isabel
AU  - Schuhmacher, Alberto J
AU  - Sibilia, Maria
AU  - Guerra, Carmen
AU  - Barbacid, Mariano
PY  - 2012
DO  - 10.1016/j.ccr.2012.08.001
UR  - https://hdl.handle.net/20.500.12105/23071
AB  - Clinical evidence indicates that mutation/activation of EGF receptors (EGFRs) is mutually exclusive with the�presence of K-RAS oncogenes in lung and colon tumors. We have validated these observations using genetically engineered mouse models. However,...
LA  - eng
PB  - Cell Press
KW  - Genes, ras
KW  - Phosphoinositide-3 Kinase Inhibitors
KW  - Signal Transduction
KW  - Adenocarcinoma
KW  - Animals
KW  - Carcinoma, Pancreatic Ductal
KW  - Cell Transformation, Neoplastic
KW  - Cells, Cultured
KW  - Epithelial Cells
KW  - ErbB Receptors
KW  - Erlotinib Hydrochloride
KW  - Humans
KW  - Mice
KW  - Mice, Transgenic
KW  - Pancreas
KW  - Pancreatic Neoplasms
KW  - Proto-Oncogene Proteins
KW  - Proto-Oncogene Proteins p21(ras)
KW  - Quinazolines
KW  - STAT3 Transcription Factor
KW  - Tumor Suppressor Protein p53
KW  - ras Proteins
TI  - EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma.
TY  - research article
ER  -