TY - GEN AU - Redzic, Jasmina S AU - Rahkola, Jeremy AU - Tran, Norman AU - Holyoak, Todd AU - Lee, Eunjeong AU - Martin-Galiano, Antonio Javier AU - Meyer, Nancy AU - Zheng, Hongjin AU - Eisenmesser, Elan PY - 2022 DO - 10.1038/s42003-022-04173-3 UR - http://hdl.handle.net/20.500.12105/15929 AB - The mucosal adaptive immune response is dependent on the production of IgA antibodies and particularly IgA1, yet opportunistic bacteria have evolved mechanisms to specifically block this response by producing IgA1 proteases (IgA1Ps). Our lab was the... LA - eng PB - Nature Publishing Group KW - Immunoglobulin A KW - Metalloproteases KW - Humans KW - Aged KW - Streptococcus KW - Bacteria KW - Virulence Factors TI - A substrate-induced gating mechanism is conserved among Gram-positive IgA1 metalloproteases TY - research article ER -