TY  - GEN
AU  - Pozo, Natividad
AU  - Zahonero, Cristina
AU  - Fernández, Paloma
AU  - Liñares, Jose M
AU  - Ayuso, Angel
AU  - Hagiwara, Masatoshi
AU  - Pérez, Angel
AU  - Ricoy, Jose R
AU  - Hernández-Laín, Aurelio
AU  - Sepúlveda, Juan M
AU  - Sánchez-Gómez, Pilar
PY  - 2013
DO  - 10.1172/JCI63623
SN  - 0021-9738
UR  - http://hdl.handle.net/20.500.12105/9727
AB  - Glioblastomas (GBMs) are very aggressive tumors that are resistant to conventional chemo- and radiotherapy. New molecular therapeutic strategies are required to effectively eliminate the subpopulation of GBM tumor-initiating cells that are responsible...
LA  - eng
PB  - American Society for Clinical Investigation (ASCI)
KW  - Animals
KW  - Antineoplastic Agents
KW  - Brain Neoplasms
KW  - Cell Line, Tumor
KW  - Cell Proliferation
KW  - Cell Survival
KW  - ErbB Receptors
KW  - Gene Expression
KW  - Gene Knockdown Techniques
KW  - Glioblastoma
KW  - Harmine
KW  - Humans
KW  - Mice
KW  - Mice, Nude
KW  - Neoplastic Stem Cells
KW  - Neural Stem Cells
KW  - Protein Stability
KW  - Protein-Serine-Threonine Kinases
KW  - Protein-Tyrosine Kinases
KW  - Proteolysis
KW  - RNA, Small Interfering
KW  - Signal Transduction
KW  - Spheroids, Cellular
KW  - Tumor Burden
KW  - Xenograft Model Antitumor Assays
TI  - Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth
TY  - research article
ER  -