TY  - JOUR
AU  - Derevyanko, Aksinya
AU  - Whittemore, Kurt
AU  - Schneider, Ralph P
AU  - Jiménez, Verónica
AU  - Bosch, Fàtima
AU  - Blasco , MA
PY  - 2017
DO  - 10.1111/acel.12677
SN  - 14749718
UR  - http://hdl.handle.net/20.500.12105/7267
AB  - The shelterin complex protects telomeres by preventing them from being degraded and recognized as double-strand DNA breaks. TRF1 is an essential component of shelterin, with important roles in telomere protection and telomere replication. We...
LA  - eng
PB  - Wiley
KW  - Trf1
KW  - Adeno-associated serotype 9 vector
KW  - Aging
KW  - Shelterin
KW  - Telomeres
KW  - Aging
KW  - Animals
KW  - Cloning, Molecular
KW  - DNA Damage
KW  - Dependovirus
KW  - Genetic Therapy
KW  - Genetic Vectors
KW  - HEK293 Cells
KW  - Humans
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Telomere
KW  - Telomeric Repeat Binding Protein 1
KW  - Transfection
TI  - Gene therapy with the TRF1 telomere gene rescues decreased TRF1 levels with aging and prolongs mouse health span
TY  - journal article
ER  -