TY  - JOUR
AU  - Trakala, Marianna
AU  - Partida, David
AU  - Salazar-Roa, Maria
AU  - Maroto, María
AU  - Wachowicz, Paulina
AU  - de Carcer Diez, Guillermo
AU  - Malumbres Martinez, Marcos
PY  - 2015
DO  - 10.1182/blood-2015-03-634402
UR  - http://hdl.handle.net/20.500.12105/10543
AB  - Polyploidization in megakaryocytes is achieved by endomitosis, a specialized cell cycle in which DNA replication is followed by aberrant mitosis. Typical mitotic regulators such as Aurora kinases or Cdk1 are dispensable for megakaryocyte maturation,...
LA  - eng
PB  - American Society of Hematology (ASH)
KW  - POLO-LIKE KINASES
KW  - VOLASERTIB BI 6727
KW  - CELL-CYCLE
KW  - AURORA-B
KW  - MEGAKARYOCYTE ENDOMITOSIS
KW  - INHIBITOR VOLASERTIB
KW  - PHASE-2 TRIAL
KW  - IN-VIVO
KW  - POLYPLOIDIZATION
KW  - MITOSIS
KW  - Animals
KW  - Cell Cycle Proteins
KW  - Cell Differentiation
KW  - Flow Cytometry
KW  - Fluorescent Antibody Technique
KW  - M Phase Cell Cycle Checkpoints
KW  - Megakaryocytes
KW  - Mice
KW  - Mice, Knockout
KW  - Protein-Serine-Threonine Kinases
KW  - Proto-Oncogene Proteins
KW  - Thrombocytopenia
TI  - Activation of the endomitotic spindle assembly checkpoint and thrombocytopenia in Plk1-deficient mice.
TY  - journal article
ER  -