TY - JOUR AU - Sánchez-Vázquez, Raúl AU - Martínez, Paula AU - Blasco, MA PY - 2021 DO - 10.1371/journal.pgen.1009410 UR - http://hdl.handle.net/20.500.12105/18203 AB - The telomere-bound shelterin complex is essential for chromosome-end protection and genomic stability. Little is known on the regulation of shelterin components by extracellular signals including developmental and environmental cues. Here, we show... LA - eng PB - Public Library of Science (PLOS) KW - Signal Transduction KW - Animals KW - Cell Transformation, Neoplastic KW - DNA Damage KW - Genomic Instability KW - Humans KW - Mice KW - Phosphatidylinositol 3-Kinases KW - Phosphorylation KW - Proteasome Endopeptidase Complex KW - Proteolysis KW - Proto-Oncogene Proteins c-akt KW - Telomere KW - Telomere Shortening KW - Telomeric Repeat Binding Protein 1 TI - AKT-dependent signaling of extracellular cues through telomeres impact on tumorigenesis. TY - journal article ER -