TY - GEN AU - Sesterhenn, Fabian AU - Yang, Che AU - Bonet, Jaume AU - Cramer, Johannes T AU - Wen, Xiaolin AU - Wang, Yimeng AU - Chiang, Chi-I AU - Abriata, Luciano A AU - Kucharska, Iga AU - Castoro, Giacomo AU - Vollers, Sabrina S AU - Galloux, Marie AU - Dheilly, Elie AU - Rosset, Stéphane AU - Corthésy, Patricia AU - Georgeon, Sandrine AU - Villard, Mélanie AU - Richard, Charles-Adrien AU - Descamps, Delphyne AU - Delgado-Romero, Teresa AU - Oricchio, Elisa AU - Rameix-Welti, Marie-Anne AU - Mas-Lloret, Vicente AU - Ervin, Sean AU - Eléouët, Jean-François AU - Riffault, Sabine AU - Bates, John T AU - Julien, Jean-Philippe AU - Li, Yuxing AU - Jardetzky, Theodore AU - Krey, Thomas AU - Correia, Bruno E PY - 2020 DO - 10.1126/science.aay5051 UR - http://hdl.handle.net/20.500.12105/14107 AB - De novo protein design has been successful in expanding the natural protein repertoire. However, most de novo proteins lack biological function, presenting a major methodological challenge. In vaccinology, the induction of precise antibody responses... LA - eng PB - American Association for the Advancement of Science (AAAS) KW - Amino Acid Motifs KW - Antibodies, Neutralizing KW - Computational Biology KW - Humans KW - Immunodominant Epitopes KW - Protein Conformation KW - Protein Engineering KW - Recombinant Fusion Proteins KW - Respiratory Syncytial Virus Vaccines KW - Respiratory Syncytial Virus, Human KW - Single-Domain Antibodies TI - De novo protein design enables the precise induction of RSV-neutralizing antibodies TY - research article ER -