TY  - JOUR
AU  - Muñoz, Sergio
AU  - Búa, Sabela
AU  - Rodriguez-Acebes, Sara
AU  - Megias Vazquez, Diego
AU  - Ortega Jimenez, Sagrario
AU  - de Martino, Alba
AU  - Mendez, Juan
PY  - 2017
DO  - 10.1016/j.celrep.2017.04.032
SN  - 22111247
UR  - http://hdl.handle.net/20.500.12105/7230
AB  - Mammalian DNA replication origins are "licensed" by the loading of DNA helicases, a reaction that is mediated by CDC6 and CDT1 proteins. After initiation of DNA synthesis, CDC6 and CDT1 are inhibited to prevent origin reactivation and DNA...
LA  - eng
PB  - Elsevier
KW  - CDC6
KW  - CDT1
KW  - DNA replication
KW  - Replication origin
KW  - TIssue dysplasia
KW  - Animals
KW  - Cell Cycle Proteins
KW  - DNA-Binding Proteins
KW  - Diarrhea, Infantile
KW  - Female
KW  - Intestinal Mucosa
KW  - Malabsorption Syndromes
KW  - Male
KW  - Mice
KW  - Nuclear Proteins
KW  - Transgenes
KW  - DNA Replication
TI  - In Vivo DNA Re-replication Elicits Lethal Tissue Dysplasias
TY  - journal article
ER  -