TY  - JOUR
AU  - Blasco, María Teresa
AU  - Navas, Carolina
AU  - Martín-Serrano, Guillermo
AU  - Martín-Díaz, Laura
AU  - Li, Jing
AU  - Morales-Cacho, Lucia
AU  - Esteban-Burgos, Laura
AU  - Perales-Patón, Javier
AU  - Bousquet-Mur, Emilie
AU  - Castellano, Eva
AU  - Jacob, Harrys K C
AU  - Cabras, Lavinia
AU  - Sainz, Bruno
AU  - Dusetti, Nelson
AU  - Iovanna, Juan
AU  - Sánchez-Bueno, Francisco
AU  - Hidalgo, Manuel
AU  - Khiabanian, Hossein
AU  - Rabadán, Raul
AU  - Graña Castro, Osvaldo
AU  - Lechuga C, Lechuga CG
AU  - Djurec M, Djurec M
AU  - Musteanu, Mónica
AU  - Drosten, Matthias
AU  - Ortega Jimenez, Sagrario
AU  - Mulero, Francisca
AU  - Guerra, Carmen
AU  - Barbacid, Mariano
AU  - Al-Shahrour, Fatima
PY  - 2019
DO  - 10.1016/j.ccell.2019.03.002
UR  - http://hdl.handle.net/20.500.12105/14772
AB  - Five-year survival for pancreatic ductal adenocarcinoma (PDAC) patients remains below 7% due to the lack of effective treatments. Here, we report that combined ablation of EGFR and c-RAF expression results in complete regression of a significant...
LA  - eng
PB  - Cell Press
KW  - Animals
KW  - Apoptosis
KW  - Carcinoma, Pancreatic Ductal
KW  - Cell Line, Tumor
KW  - Cell Proliferation
KW  - ErbB Receptors
KW  - Erlotinib Hydrochloride
KW  - Gefitinib
KW  - Gene Expression Regulation, Neoplastic
KW  - Humans
KW  - Mice, 129 Strain
KW  - Mice, Inbred C57BL
KW  - Mice, Transgenic
KW  - Mutation
KW  - Pancreatic Neoplasms
KW  - Protein Kinase Inhibitors
KW  - Proto-Oncogene Proteins c-raf
KW  - Proto-Oncogene Proteins p21(ras)
KW  - Signal Transduction
KW  - Tumor Burden
KW  - Tumor Suppressor Protein p53
KW  - Xenograft Model Antitumor Assays
TI  - Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF.
TY  - journal article
ER  -