TY - GEN AU - Martinez-Abadias, Neus AU - Mateu Estivill, Roger AU - Sastre Tomas, Jaume AU - Perrine, Susan Motch AU - Yoon, Melissa AU - Robert-Moreno, Alexandre AU - Swoger, Jim AU - Russo, Lucia AU - Kawasaki, Kazuhiko AU - Richtsmeier, Joan AU - Sharpe, James PY - 2018 DO - 10.7554/eLife.36405 SN - 2050-084X UR - https://hdl.handle.net/20.500.12105/22556 AB - The earliest developmental origins of dysmorphologies are poorly understood in many congenital diseases. They often remain elusive because the first signs of genetic misregulation may initiate as subtle changes in gene expression, which are hard to... LA - eng PB - eLife Sciences Publications KW - Disease Models, Animal KW - Biometry KW - Gene Expression Regulation, Developmental KW - Gene Expression Profiling KW - Animals KW - Receptor, Fibroblast Growth Factor, Type 2 KW - Tomography, X-Ray Computed KW - Acrocephalosyndactylia KW - Mice, Inbred C57BL KW - Mutation, Missense TI - Quantification of gene expression patterns to reveal the origins of abnormal morphogenesis TY - research article ER -