TY  - GEN
AU  - Martinez, Natalia
AU  - Garcia-Dominguez, Carlota A
AU  - Domingo, Beatriz
AU  - Oliva-Martinez, Jose Luis
AU  - Zarich-Dimitrievich, Natasha
AU  - Sanchez, Agustin
AU  - Gutiérrez-Eisman, Silvia
AU  - Llopis, Juan
AU  - Rojas-Cabañeros, Jose Maria
PY  - 2007
DO  - 10.1016/j.cellsig.2007.07.008
UR  - https://hdl.handle.net/20.500.12105/26129
AB  - Sprouty2 has been widely implicated in the negative regulation of the fibroblast growth factor receptor-extracellular regulated kinase (ERK) pathway. Sprouty2 directly interacts with the adapter protein Grb2, member of the receptor tyrosine...
LA  - eng
PB  - Elsevier
KW  - hSpry2
KW  - Grb2
KW  - SH3
KW  - ERK
KW  - FGFR
KW  - Amino Acid Sequence
KW  - Animals
KW  - Binding Sites
KW  - Extracellular Signal-Regulated MAP Kinases
KW  - Fluorescence Resonance Energy Transfer
KW  - GRB2 Adaptor Protein
KW  - Humans
KW  - Intracellular Signaling Peptides and Proteins
KW  - Membrane Proteins
KW  - Mice
KW  - Molecular Sequence Data
KW  - Mutation
KW  - NIH 3T3 Cells
KW  - Proline
KW  - Protein Binding
KW  - Protein Interaction Mapping
KW  - Protein Transport
KW  - Signal Transduction
KW  - ras Proteins
KW  - src Homology Domains
TI  - Sprouty2 binds Grb2 at two different proline-rich regions, and the mechanism of ERK inhibition is independent of this interaction
TY  - research article
ER  -