TY  - JOUR
AU  - Muñoz-Hernández, Hugo
AU  - Pal, Mohinder
AU  - Rodríguez, Carlos F
AU  - Fernandez-Leiro, Rafael
AU  - Prodromou, Chrisostomos
AU  - Pearl, Laurence H
AU  - Llorca Blanco, Oscar Antonio
AU  - Muñoz-Hernández, Hugo
AU  - Pal, Mohinder
AU  - Rodríguez, Carlos F
AU  - Fernandez-Leiro, Rafael
AU  - Prodromou, Chrisostomos
AU  - Pearl, Laurence H
PY  - 2019
DO  - 10.1126/sciadv.aaw1616
SN  - 2375-2548
UR  - http://hdl.handle.net/20.500.12105/7838
AB  - The human R2TP complex (RUVBL1-RUVBL2-RPAP3-PIH1D1) is an HSP90 co-chaperone required for the maturation of several essential multiprotein complexes, including RNA polymerase II, small nucleolar ribonucleoproteins, and PIKK complexes such as mTORC1...
LA  - eng
KW  - HSP90
KW  - MTOR
KW  - COMPLEX
KW  - TEL2
KW  - DOMAIN
KW  - BINDING
KW  - COCHAPERONE
TI  - Structural mechanism for regulation of the AAA-ATPases RUVBL1-RUVBL2 in the R2TP co-chaperone revealed by cryo-EM
TY  - journal article
ER  -