TY - JOUR AU - Sanchez-Ramon, Silvia AU - Conejero, Laura AU - Netea, Mihai G AU - Sancho, David AU - Palomares, Óscar AU - Subiza, José Luis PY - 2018 DO - 10.3389/fimmu.2018.02936 SN - 1664-3224 UR - http://hdl.handle.net/20.500.12105/7126 AB - Challenge with specific microbial stimuli induces long lasting epigenetic changes in innate immune cells that result in their enhanced response to a second challenge by the same or unrelated microbial insult, a process referred to as trained immunity.... LA - eng PB - Frontiers Media KW - PRR-ligands KW - Adjuvants KW - Immunostimulants KW - Innate immunity KW - Pattern recognition receptors (PRRs) KW - Trained immunity KW - Trained immunity-based vaccines (TIbV) KW - Vaccines TI - Trained Immunity-Based Vaccines: A New Paradigm for the Development of Broad-Spectrum Anti-infectious Formulations TY - journal article ER -