TY  - JOUR
AU  - Macías, Álvaro
AU  - Díaz-Larrosa, J Jaime
AU  - Blanco, Yaazan
AU  - Fanjul, Víctor
AU  - González-Gómez, Cristina
AU  - Gonzalo, Pilar
AU  - Andres-Manzano, Maria J.
AU  - da Rocha, Andre Monteiro
AU  - Ponce-Balbuena, Daniela
AU  - Allan, Andrew
AU  - Filgueiras-Rama, David
AU  - Jalife, Jose
AU  - Andres, Vicente
PY  - 2022
DO  - 10.1093/cvr/cvab055
SN  - 0008-6363
UR  - http://hdl.handle.net/20.500.12105/15202
AB  - Hutchinson-Gilford progeria syndrome (HGPS) is an ultrarare laminopathy caused by expression of progerin, a lamin A variant, also present at low levels in non-HGPS individuals. HGPS patients age and die prematurely, predominantly from cardiovascular...
LA  - eng
PB  - Oxford University Press
KW  - Action Potentials
KW  - Animals
KW  - Anti-Arrhythmia Agents
KW  - Arrhythmias, Cardiac
KW  - Cytoskeleton
KW  - Disease Models, Animal
KW  - Excitation Contraction Coupling
KW  - Female
KW  - Genetic Predisposition to Disease
KW  - Heart Conduction System
KW  - Heart Rate
KW  - Lamin Type A
KW  - Male
KW  - Mice, Mutant Strains
KW  - Mutation
KW  - Myocytes, Cardiac
KW  - Paclitaxel
KW  - Progeria
KW  - Refractory Period, Electrophysiological
KW  - Swine
KW  - Swine, Miniature
KW  - Tubulin
TI  - Paclitaxel mitigates structural alterations and cardiac conduction system defects in a mouse model of Hutchinson-Gilford progeria syndrome.
TY  - journal article
ER  -