TY - JOUR AU - Garcia-Carpizo, Veronica AU - Ruiz-Llorente, Sergio AU - Sarmentero, Jacinto AU - GraƱa Castro, Osvaldo AU - Pisano, David G AU - Barrero, Maria Jose PY - 2018 DO - 10.1186/s13072-018-0197-x SN - 1756-8935 UR - http://hdl.handle.net/20.500.12105/6821 AB - BACKGROUND: The reported antitumor activity of the BET family bromodomain inhibitors has prompted the development of inhibitors against other bromodomains. However, the human genome encodes more than 60 different bromodomains and most of them remain... LA - eng PB - BioMed Central (BMC) KW - Bromodomains KW - Cancer KW - Epigenetics KW - Proliferation KW - CREB-Binding Protein KW - Cell Cycle KW - Cell Proliferation KW - E1A-Associated p300 Protein KW - Enhancer Elements, Genetic KW - GATA1 Transcription Factor KW - Gene Expression Regulation, Neoplastic KW - Humans KW - K562 Cells KW - Leukemia, Myelogenous, Chronic, BCR-ABL Positive KW - Protein Domains KW - Proto-Oncogene Proteins c-myc KW - Transcription, Genetic TI - CREBBP/EP300 bromodomains are critical to sustain the GATA1/MYC regulatory axis in proliferation TY - journal article ER -