TY - GEN AU - Calero, Miguel AU - Gómez-Ramos, Alberto AU - Calero, Olga AU - Soriano, Eduardo AU - Avila, Jesús AU - Medina, Miguel PY - 2015 DO - 10.3389/fncel.2015.00138 SN - 1662-5102 UR - http://hdl.handle.net/20.500.12105/9686 AB - Familial Alzheimer's disease (AD), mostly associated with early onset, is caused by mutations in three genes (APP, PSEN1, and PSEN2) involved in the production of the amyloid β peptide. In contrast, the molecular mechanisms that trigger the most... LA - eng PB - Frontiers Media KW - Alzheimer KW - GWAS KW - Epistasis KW - Exome KW - Neurodegeneration KW - Rare variants KW - Risk factors KW - Somatic mutations TI - Additional mechanisms conferring genetic susceptibility to Alzheimer's disease TY - research article ER -