TY - GEN AU - Redrado-Hernández, Sergio AU - Macías-León, Javier AU - Castro-López, Jorge AU - Belén Sanz, Ana AU - Dolader, Elena AU - Arias, Maykel AU - González-Ramírez, Andrés Manuel AU - Sánchez-Navarro, David AU - Petryk, Yuliya AU - Farkaš, Vladimír AU - Vincke, Cécile AU - Muyldermans, Serge AU - Garcia-Barbazan, Irene AU - Del Agua, Celia AU - Zaragoza, Oscar AU - Arroyo, Javier AU - Pardo, Julián AU - Gálvez, Eva M AU - Hurtado-Guerrero, Ramon AU - Redrado-Hernández, Sergio AU - Macías-León, Javier AU - Castro-López, Jorge AU - Belén Sanz, Ana AU - Dolader, Elena AU - Arias, Maykel AU - González-Ramírez, Andrés Manuel AU - Sánchez-Navarro, David AU - Petryk, Yuliya AU - Farkaš, Vladimír AU - Vincke, Cécile AU - Muyldermans, Serge AU - Del Agua, Celia AU - Zaragoza, Oscar AU - Arroyo, Javier AU - Pardo, Julián AU - Gálvez, Eva M AU - Hurtado-Guerrero, Ramon PY - 2024 SN - 1433-7851 SN - 10.1002/anie.202405823 UR - https://hdl.handle.net/20.500.12105/25091 AB - Invasive fungal disease accounts for about 3.8 million deaths annually, an unacceptable rate that urgently prompts the discovery of new knowledge-driven treatments. We report the use of camelid single-domain nanobodies (Nbs) against fungal... LA - eng PB - Wiley KW - Glucanosyltransferases KW - Cell wall KW - Invasive fungal infections KW - Nanobodies KW - Transglycosylases KW - Animals KW - Antifungal Agents KW - Aspergillus fumigatus KW - Catalytic Domain KW - Cryptococcus neoformans KW - Glucan Endo-1,3-beta-D-Glucosidase KW - Mice KW - Single-Domain Antibodies TI - Broad Protection against Invasive Fungal Disease from a Nanobody Targeting the Active Site of Fungal β-1,3-Glucanosyltransferases TY - research article ER -