TY  - GEN
AU  - Garcia-Ferrer, Irene
AU  - Arêde, Pedro
AU  - Gómez-Blanco, Josué
AU  - Luque, Daniel
AU  - Duquerroy, Stephane
AU  - Castón, José R
AU  - Goulas, Theodoros
AU  - Gomis-Rüth, F Xavier
PY  - 2015
DO  - 10.1073/pnas.1506538112
SN  - 0027-8424
UR  - http://hdl.handle.net/20.500.12105/9998
AB  - The survival of commensal bacteria requires them to evade host peptidases. Gram-negative bacteria from the human gut microbiome encode a relative of the human endopeptidase inhibitor, α2-macroglobulin (α2M). Escherichia coli α2M (ECAM) is a ∼ 180-kDa...
LA  - eng
PB  - National Academy of Sciences
KW  - X-ray crystal structure
KW  - Conformational rearrangement
KW  - Cryo-electron microscopy
KW  - Gut microbiome
KW  - Protein inhibitor
KW  - Amino Acid Sequence
KW  - Binding Sites
KW  - Crystallography, X-Ray
KW  - Endopeptidases
KW  - Escherichia coli
KW  - Escherichia coli Proteins
KW  - Gastrointestinal Tract
KW  - Humans
KW  - Membrane Proteins
KW  - Microbiota
KW  - Microscopy, Electron
KW  - Models, Molecular
KW  - Molecular Sequence Data
KW  - Molecular Weight
KW  - Peptide Hydrolases
KW  - Protease Inhibitors
KW  - Protein Multimerization
KW  - Protein Structure, Secondary
KW  - Protein Structure, Tertiary
KW  - alpha-Macroglobulins
TI  - Structural and functional insights into Escherichia coli α2-macroglobulin endopeptidase snap-trap inhibition
TY  - research article
ER  -