TY - GEN AU - Nogueiras, Rubén AU - Sabio, Guadalupe PY - 2021 DO - 10.1007/s00125-020-05327-w UR - http://hdl.handle.net/20.500.12105/18912 AB - Obesity, which has long since reached epidemic proportions worldwide, is associated with long-term stress to a variety of organs and results in diseases including type 2 diabetes. In the brain, overnutrition induces hypothalamic stress associated with... LA - eng PB - Springer KW - Agouti-Related Protein KW - Animals KW - Brain KW - Endoplasmic Reticulum Stress KW - Energy Metabolism KW - Feeding Behavior KW - Glucose KW - Humans KW - Hypothalamo-Hypophyseal System KW - Hypothalamus KW - Insulin KW - JNK Mitogen-Activated Protein Kinases KW - Leptin KW - Metabolic Diseases KW - Mitogen-Activated Protein Kinase 10 KW - Mitogen-Activated Protein Kinase 8 KW - Mitogen-Activated Protein Kinase 9 KW - Neurons KW - Obesity KW - Thyroid Gland KW - Weight Gain TI - Brain JNK and metabolic disease. TY - review article ER -