TY  - GEN
AU  - Cordero-Barreal, Alfonso
AU  - Caleiras, Eduardo
AU  - López de Maturana, Evangelina
AU  - Monteagudo, María
AU  - Martínez-Montes, Ángel M
AU  - Letón, Rocío
AU  - Gil, Eduardo
AU  - Álvarez-Escolá, Cristina
AU  - Regojo, Rita M
AU  - Andía, Víctor
AU  - Marazuela, Mónica
AU  - Guadalix, Sonsoles
AU  - Calatayud, María
AU  - Robles-Díaz, Luis
AU  - Aguirre, Miguel
AU  - Cano, Juana M
AU  - Díaz, José Ángel
AU  - Saavedra, Pilar
AU  - Lamas, Cristina
AU  - Azriel, Sharona
AU  - Sastre, Julia
AU  - Aller, Javier
AU  - Leandro-García, Luis J
AU  - Calsina, Bruna
AU  - Roldán-Romero, Juan María
AU  - Santos, María
AU  - Lanillos, Javier
AU  - Cascon Soriano, Alberto
AU  - Robledo Batanero, Mercedes
AU  - Montero-Conde, Cristina
AU  - Rodriguez Antona, Cristina
PY  - 2020
UR  - https://hdl.handle.net/20.500.12105/27205
AB  - The identification of markers able to determine medullary thyroid cancer (MTC) patients at high-risk of disease progression is critical to improve their clinical management and outcome. Previous studies have suggested that expression of the stem cell...
AB  - To evaluate CD133 impact on disease progression in MTC and explore the regulatory mechanisms leading to the upregulation of this protein in aggressive tumors.
AB  - We compiled a series of 74 MTCs with associated clinical data and characterized them for mutations in RET and RAS proto-oncogenes, presumed to be related with disease clinical behavior.
AB  - We found that CD133 immunohistochemical expression was associated with adverse clinicopathological features and predicted a reduction in time to disease progression even when only RET-mutated cases were considered in the analysis (log-rank test...
AB  - Our results suggest that CD133 expression may be a useful tool to identify MTC patients with poor prognosis, who may benefit from a more extensive primary surgical management and follow-up.
LA  - eng
PB  - Endocrine Society
KW  - RAS
KW  - RET
KW  - calcitonin expression and tumor emboli
KW  - disease progression
KW  - immunohistochemistry
TI  - CD133 Expression in Medullary Thyroid Cancer Cells Identifies Patients with Poor Prognosis.
TY  - research article
ER  -