TY - JOUR AU - Brandi, Paola AU - Conejero, Laura AU - Cueto, Francisco J AU - Martínez-Cano, Sarai AU - Dunphy, Gillian AU - Gómez, Manuel J AU - Relaño, Carlos AU - Saz-Leal, Paula AU - Enamorado, Michel AU - Quintas, Ana AU - Dopazo, Ana AU - Amores-Iniesta, Joaquin AU - Del Fresno, Carlos AU - Nistal-Villán, Estanislao AU - Ardavín, Carlos AU - Nieto, Antonio AU - Casanovas, Miguel AU - Subiza, José Luis AU - Sancho, David PY - 2022 DO - 10.1016/j.celrep.2021.110184 UR - http://hdl.handle.net/20.500.12105/15092 AB - MV130 is an inactivated polybacterial mucosal vaccine that confers protection to patients against recurrent respiratory infections, including those of viral etiology. However, its mechanism of action remains poorly understood. Here, we find that... LA - eng PB - Cell Press KW - Administration, Intranasal KW - Animals KW - Antibodies, Viral KW - Bacteria KW - Bacterial Vaccines KW - Candidiasis KW - Cell Line KW - Chlorocebus aethiops KW - Cytokines KW - Humans KW - Immunity, Mucosal KW - Influenza A virus KW - L Cells KW - Lung KW - Metformin KW - Mice KW - Mice, Inbred C57BL KW - Mice, Knockout KW - Monocytes KW - Orthomyxoviridae Infections KW - Respiratory Mucosa KW - Respiratory Tract Infections KW - Vaccines, Inactivated TI - Trained immunity induction by the inactivated mucosal vaccine MV130 protects against experimental viral respiratory infections. TY - journal article ER -