TY  - JOUR
AU  - Lopez-Contreras, Andres J
AU  - Specks, Julia
AU  - Barlow, Jacqueline H
AU  - Ambrogio, Chiara
AU  - Desler, Claus
AU  - Vikingsson, Svante
AU  - Rodrigo-Perez, Sara
AU  - Green, Henrik
AU  - Rasmussen, Lene Juel
AU  - Nussenzweig, André
AU  - Fernandez-Capetillo, Oscar
PY  - 2015
DO  - 10.1101/gad.256958.114
UR  - http://hdl.handle.net/20.500.12105/10264
AB  - In Saccharomyces cerevisiae, absence of the checkpoint kinase Mec1 (ATR) is viable upon mutations that increase the activity of the ribonucleotide reductase (RNR) complex. Whether this pathway is conserved in mammals remains unknown. Here we show that...
LA  - eng
PB  - Cold Spring Harbor Laboratory Press
KW  - Chromosome Breakage
KW  - Animals
KW  - Cell Line
KW  - Cell Survival
KW  - Cells, Cultured
KW  - Chromosome Fragile Sites
KW  - Enzyme Activation
KW  - Fibroblasts
KW  - Gene Dosage
KW  - Humans
KW  - Longevity
KW  - Mice
KW  - Nucleosides
KW  - Protein-Serine-Threonine Kinases
KW  - Ribonucleoside Diphosphate Reductase
KW  - Survival Analysis
TI  - Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice.
TY  - journal article
ER  -