TY  - JOUR
AU  - Murga, Matilde
AU  - Fernandez-Capetillo, Oscar
AU  - Field, S J
AU  - Moreno, B
AU  - Borlado, L R
AU  - Fujiwara, Y
AU  - Balomenos, D
AU  - Vicario, A
AU  - Carrera, A C
AU  - Orkin, S H
AU  - Greenberg, M E
AU  - Zubiaga, A M
PY  - 2001
DO  - 10.1016/s1074-7613(01)00254-0
SN  - 1074-7613
UR  - http://hdl.handle.net/20.500.12105/17701
AB  - E2Fs are important regulators of proliferation, differentiation, and apoptosis. Here we characterize the phenotype of mice deficient in E2F2. We show that E2F2 is required for immunologic self-tolerance. E2F2(-/-) mice develop late-onset autoimmune...
LA  - eng
PB  - Cell Press
KW  - Cell Cycle Proteins
KW  - DNA-Binding Proteins
KW  - Animals
KW  - Apoptosis
KW  - Autoimmune Diseases
KW  - Autoimmunity
KW  - Cell Division
KW  - Chimera
KW  - Clonal Deletion
KW  - E2F Transcription Factors
KW  - E2F1 Transcription Factor
KW  - E2F2 Transcription Factor
KW  - Gene Expression Regulation
KW  - Glomerulonephritis, Membranoproliferative
KW  - H-Y Antigen
KW  - Humans
KW  - Immunologic Memory
KW  - Inflammation
KW  - Jurkat Cells
KW  - Lymphocyte Activation
KW  - Male
KW  - Mice
KW  - Mice, Inbred BALB C
KW  - Mice, Inbred C57BL
KW  - Mice, Knockout
KW  - Mutagenesis, Site-Directed
KW  - Receptors, Antigen, T-Cell
KW  - Recombinant Fusion Proteins
KW  - Repressor Proteins
KW  - S Phase
KW  - Self Tolerance
KW  - Splenomegaly
KW  - T-Lymphocytes
KW  - Thymus Gland
KW  - Transcription Factors
KW  - Transfection
TI  - Mutation of E2F2 in mice causes enhanced T lymphocyte proliferation, leading to the development of autoimmunity.
TY  - journal article
ER  -