TY  - GEN
AU  - Meagher, Nicola S
AU  - Hamilton, Phineas
AU  - Milne, Katy
AU  - Thornton, Shelby
AU  - Harris, Bronwyn
AU  - Weir, Ashley
AU  - Alsop, Jennifer
AU  - Bisinoto, Christiani
AU  - Brenton, James D
AU  - Brooks-Wilson, Angela
AU  - Chiu, Derek S
AU  - Cushing-Haugen, Kara L
AU  - Fereday, Sian
AU  - Garsed, Dale W
AU  - Gayther, Simon A
AU  - Gentry-Maharaj, Aleksandra
AU  - Gilks, Blake
AU  - Jimenez-Linan, Mercedes
AU  - Kennedy, Catherine J
AU  - Le, Nhu D
AU  - Piskorz, Anna M
AU  - Riggan, Marjorie J
AU  - Shah, Mitul
AU  - Singh, Naveena
AU  - Talhouk, Aline
AU  - Widschwendter, Martin
AU  - Bowtell, David D L
AU  - Candido Dos Reis, Francisco J
AU  - Cook, Linda S
AU  - Fortner, Renée T
AU  - García, María J
AU  - Harris, Holly R
AU  - Huntsman, David G
AU  - Karnezis, Anthony N
AU  - Köbel, Martin
AU  - Menon, Usha
AU  - Pharoah, Paul D P
AU  - Doherty, Jennifer A
AU  - Anglesio, Michael S
AU  - Pike, Malcolm C
AU  - Pearce, Celeste Leigh
AU  - Friedlander, Michael L
AU  - DeFazio, Anna
AU  - Nelson, Brad H
AU  - Ramus, Susan J
PY  - 2023
UR  - https://hdl.handle.net/20.500.12105/26527
AB  - Mucinous ovarian carcinoma (MOC) is a rare histotype of ovarian cancer, with low response rates to standard chemotherapy, and very poor survival for patients diagnosed at advanced stage. There is a limited understanding of the MOC immune landscape,...
AB  - We performed multicolor immunohistochemistry (IHC) and immunofluorescence (IF) on tissue microarrays in a cohort of 126 MOC patients. Cell densities were calculated in the epithelial and stromal components for tumor-associated macrophages...
AB  - Mean densities of PD1+ cells, PD-L1- macrophages, CD4+ and CD8+ T cells, and FOXP3+ Tregs were higher in the stroma compared to the epithelium. Tumors from advanced (Stage III/IV) MOC had greater epithelial infiltration of PD-L1- macrophages, and...
AB  - In summary, MOCs are mostly immunogenically 'cold', suggesting they may have limited response to current immunotherapies.
LA  - eng
PB  - Elevier
KW  - Immune infiltrate
KW  - Mucinous ovarian carcinoma
KW  - Rare histotype
TI  - Profiling the immune landscape in mucinous ovarian carcinoma.
TY  - research article
ER  -