TY - JOUR AU - Iglesias, Ainhoa AU - Murga, Matilde AU - Laresgoiti, Usua AU - Skoudy, Anouchka AU - Bernales, Irantzu AU - Fullaondo, Asier AU - Moreno, Bernardino AU - Lloreta, José AU - Field, Seth J AU - Real, Francisco X AU - Zubiaga, Ana M PY - 2004 DO - 10.1172/JCI18879 SN - 0021-9738 UR - http://hdl.handle.net/20.500.12105/17707 AB - E2F transcription factors are thought to be key regulators of cell growth control. Here we use mutant mouse strains to investigate the function of E2F1 and E2F2 in vivo. E2F1/E2F2 compound-mutant mice develop nonautoimmune insulin-deficient diabetes... LA - eng PB - American Society for Clinical Investigation (ASCI) KW - Cell Cycle Proteins KW - Animals KW - Apoptosis KW - Cell Differentiation KW - Cell Division KW - DNA Replication KW - DNA-Binding Proteins KW - Diabetes Mellitus, Type 1 KW - E2F Transcription Factors KW - E2F1 Transcription Factor KW - E2F2 Transcription Factor KW - Exocrine Pancreatic Insufficiency KW - Islets of Langerhans KW - Male KW - Mice KW - Mice, Knockout KW - Microscopy, Electron KW - Pancreas KW - Trans-Activators KW - Transcription Factors TI - Diabetes and exocrine pancreatic insufficiency in E2F1/E2F2 double-mutant mice. TY - journal article ER -