TY  - GEN
AU  - Klein Hesselink, Esther N
AU  - Zafon, Carles
AU  - Villalmanzo, Núria
AU  - Iglesias, Carmela
AU  - van Hemel, Bettien M
AU  - Klein Hesselink, Mariëlle S
AU  - Montero-Conde, Cristina
AU  - Buj, Raquel
AU  - Mauricio, Dídac
AU  - Peinado, Miguel A
AU  - Puig-Domingo, Manel
AU  - Riesco-Eizaguirre, Garcilaso
AU  - Reverter, Jordi L
AU  - Robledo Batanero, Mercedes
AU  - Links, Thera P
AU  - Jordà, Mireia
PY  - 2018
UR  - https://hdl.handle.net/20.500.12105/27206
AB  - Global DNA hypomethylation is a major event for the development and progression of cancer, although the significance in thyroid cancer remains unclear. Therefore, we aimed to investigate its role in thyroid cancer progression and its potential as a...
AB  - Global hypomethylation of Alu repeats was used as a surrogate marker for DNA global hypomethylation, and was assessed using the Quantification of Unmethylated Alu technique. Mutations in BRAF and RAS were determined by Sanger sequencing.
AB  - Ninety primary thyroid tumors were included [28 low-risk differentiated thyroid cancer (DTC), 13 pediatric DTC, 33 distant metastatic DTC, 7 poorly differentiated thyroid cancer (PDTC), and 9 anaplastic thyroid cancer (ATC)], as well as 24 distant...
AB  - Distant metastatic DTC, PDTC, and ATC were increasingly affected by global Alu hypomethylation, suggesting that this epigenetic entity may be involved in thyroid cancer progression and dedifferentiation.
LA  - eng
PB  - Endocrine Society
TI  - Increased Global DNA Hypomethylation in Distant Metastatic and Dedifferentiated Thyroid Cancer.
TY  - research article
ER  -