TY - GEN AU - Betancor, Gilberto AU - Garriga, Cesar AU - Puertas, Maria C AU - Nevot, María AU - Anta, Lourdes AU - Blanco, José L AU - Pérez-Elías, María-Jesús AU - de Mendoza, Carmen AU - Martínez, Miguel A AU - Martinez-Picado, Javier AU - Menéndez-Arias, Luis AU - Resistance Platform of the Spanish AIDS Research Network (ResRIS) AU - Perez-Olmeda, Mayte AU - Alcamí, José PY - 2012 DO - 10.1186/1742-4690-9-68 SN - 1742-4690 UR - http://hdl.handle.net/20.500.12105/7171 AB - BACKGROUND: Thymidine analogue resistance mutations (TAMs) selected under treatment with nucleoside analogues generate two distinct genotypic profiles in the HIV-1 reverse transcriptase (RT): (i) TAM1: M41L, L210W and T215Y, and (ii) TAM2: D67N, K70R... LA - eng PB - BioMed Central (BMC) KW - Adenine KW - Anti-HIV Agents KW - Deoxycytidine KW - Emtricitabine KW - HIV Infections KW - HIV Reverse Transcriptase KW - HIV-1 KW - Humans KW - Molecular Sequence Data KW - Organophosphonates KW - Selection, Genetic KW - Sequence Analysis, DNA KW - Tenofovir KW - Treatment Failure KW - Drug Resistance, Viral KW - Mutation, Missense TI - Clinical, virological and biochemical evidence supporting the association of HIV-1 reverse transcriptase polymorphism R284K and thymidine analogue resistance mutations M41L, L210W and T215Y in patients failing tenofovir/emtricitabine therapy TY - research article ER -