TY - JOUR AU - Gonzalez-Teran, Barbara AU - Lopez, Juan Antonio AU - Rodriguez, Elena AU - Leiva-Vega, Luis AU - Martinez-Martinez, Sara AU - Bernal, Juan Antonio AU - Jimenez-Borreguero, Luis J. AU - Redondo, Juan Miguel AU - Vazquez, Jesus AU - Sabio, Guadalupe PY - 2016 DO - 10.1038/ncomms10477 SN - 2041-1723 UR - http://hdl.handle.net/20.500.12105/5250 AB - Disrupted organ growth leads to disease development. Hypertrophy underlies postnatal heart growth and is triggered after stress, but the molecular mechanisms involved in these processes are largely unknown. Here we show that cardiac activation of p38... LA - eng PB - Nature Publishing Group KW - INDUCED CARDIAC-HYPERTROPHY KW - SIGNALING PATHWAYS KW - PRESSURE-OVERLOAD KW - UBIQUITIN LIGASE KW - ANGIOTENSIN-II KW - KINASE PLAYS KW - S6 KINASE KW - P38 KW - MICE KW - CARDIOMYOPATHY TI - p38 gamma and delta promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation TY - journal article ER -