TY - GEN AU - Castilla-Ortega, Estela AU - Hoyo-Becerra, Carolina AU - Pedraza, Carmen AU - Chun, Jerold AU - Rodríguez De Fonseca, Fernando AU - Estivill-Torrús, Guillermo AU - Santín, Luis J PY - 2011 DO - 10.1371/journal.pone.0025522 UR - http://hdl.handle.net/20.500.12105/17017 AB - BACKGROUND: The lysophosphatidic acid LPA₁ receptor regulates plasticity and neurogenesis in the adult hippocampus. Here, we studied whether absence of the LPA₁ receptor modulated the detrimental effects of chronic stress on hippocampal neurogenesis... LA - eng PB - Public Library of Science (PLOS) KW - Animales KW - Ansiedad KW - recuento de células KW - proliferación celular KW - Supervivencia Celular KW - Conducta Exploratoria KW - técnicas de inactivación genética KW - Hipocampo KW - Masculino KW - Memoria KW - Ratones KW - proteínas asociadas a microtúbulos KW - células madre nerviosas KW - Neurogénesis KW - Neuronas KW - Neuroglía KW - tamaño de los órganos KW - receptores de ácidos lisofosfatídicos KW - restricción física KW - Conducta Espacial KW - Estrés Psicológico KW - Anxiety KW - Apoptosis KW - Cell Proliferation KW - Cell Survival KW - Exploratory Behavior KW - Gene Knockout Techniques KW - Hippocampus KW - Male KW - Memory KW - Memory Disorders KW - Memory, Short-Term KW - Mice KW - Microtubule-Associated Proteins KW - Neural Stem Cells KW - Neurogenesis KW - Neuroglia KW - Neurons KW - Neuropeptides KW - Organ Size KW - Receptors, Lysophosphatidic Acid KW - Restraint, Physical KW - Spatial Behavior KW - Stress, Psychological KW - Animals TI - Aggravation of chronic stress effects on hippocampal neurogenesis and spatial memory in LPA₁ receptor knockout mice. TY - research article ER -