TY - GEN AU - Sannino, Giuseppina AU - Marchetto, Aruna AU - Ranft, Andreas AU - Jabar, Susanne AU - Zacherl, Constanze AU - Alba-Rubio, Rebeca AU - Stein, Stefanie AU - Wehweck, Fabienne S AU - Kiran, Merve M AU - Hölting, Tilman L B AU - Musa, Julian AU - Romero-Pérez, Laura AU - Cidre-Aranaz, Florencia AU - Knott, Maximilian M L AU - Li, Jing AU - Jürgens, Heribert AU - Sastre, Ana AU - Alonso, Javier AU - Da Silveira, Willian AU - Hardiman, Gary AU - Gerke, Julia S AU - Orth, Martin F AU - Hartmann, Wolfgang AU - Kirchner, Thomas AU - Ohmura, Shunya AU - Dirksen, Uta AU - Grünewald, Thomas G P PY - 2019 DO - 10.1016/j.ebiom.2019.08.002 SN - 2352-3964 UR - http://hdl.handle.net/20.500.12105/9164 AB - BACKGROUND: Up to 30-40% of Ewing sarcoma (EwS) patients with non-metastatic disease develop local or metastatic relapse within a time span of 2-10 years. This is in part caused by the absence of prognostic biomarkers that can identify high-risk... LA - eng PB - Elsevier KW - Biomarker KW - Ewing sarcoma KW - Patient outcome KW - Risk-stratification KW - SOX2 KW - Biomarkers KW - Biomarkers, Tumor KW - Female KW - Humans KW - Immunohistochemistry KW - Male KW - Neoplasm Recurrence, Local KW - Neoplasm Staging KW - Prognosis KW - Risk Factors KW - SOXB1 Transcription Factors KW - Sarcoma, Ewing KW - Gene Expression TI - Gene expression and immunohistochemical analyses identify SOX2 as major risk factor for overall survival and relapse in Ewing sarcoma patients TY - research article ER -