TY  - JOUR
AU  - Toledo, Luis I
AU  - Murga, Matilde
AU  - Gutierrez-Martinez, Paula
AU  - Soria, Rebeca
AU  - Fernandez-Capetillo, Oscar
PY  - 2008
DO  - 10.1101/gad.452308
SN  - 0890-9369
UR  - http://hdl.handle.net/20.500.12105/17686
AB  - The ATR kinase is a key transducer of "replicative stress," the type of genomic damage that has been postulated to be induced by oncogenes. Here we describe a cellular system in which we can unleash ATR activity at will, in the absence of any actual...
LA  - eng
PB  - Cold Spring Harbor Laboratory Press
KW  - DNA Breaks
KW  - Animals
KW  - Ataxia Telangiectasia Mutated Proteins
KW  - Cell Cycle
KW  - Cell Cycle Proteins
KW  - Cell Line, Transformed
KW  - Cell Line, Tumor
KW  - Cellular Senescence
KW  - Cyclin-Dependent Kinase Inhibitor p16
KW  - DNA-Binding Proteins
KW  - Enzyme Activation
KW  - Humans
KW  - Mice
KW  - Protein Serine-Threonine Kinases
KW  - Signal Transduction
KW  - Tumor Suppressor Protein p53
KW  - Tumor Suppressor Proteins
TI  - ATR signaling can drive cells into senescence in the absence of DNA breaks.
TY  - journal article
ER  -