TY - JOUR AU - García-Gutiérrez, Lucía AU - Bretones, Gabriel AU - Molina, Ester AU - Arechaga, Ignacio AU - Symonds, Catherine AU - Acosta, Juan C AU - Blanco, Rosa AU - Fernández, Adrián AU - Alonso, Leticia AU - Sicinski, Piotr AU - Barbacid, Mariano AU - Santamaría, David AU - León, Javier PY - 2019 DO - 10.1038/s41598-019-54917-1 SN - 2045-2322 UR - http://hdl.handle.net/20.500.12105/9352 AB - Cell cycle stimulation is a major transforming mechanism of Myc oncoprotein. This is achieved through at least three concomitant mechanisms: upregulation of cyclins and Cdks, downregulation of the Cdk inhibitors p15 and p21 and the degradation of p27.... LA - eng PB - Nature Publishing Group TI - Myc stimulates cell cycle progression through the activation of Cdk1 and phosphorylation of p27 TY - journal article ER -