TY - GEN AU - Nieto, Amelia AU - Pozo Sanchez, Francisco AU - Vidal-García, Matxalen AU - Omeñaca, Manuel AU - Casas Flecha, Inmaculada AU - Falcon, Ana PY - 2017 DO - 10.3389/fmicb.2017.00575 SN - 1664-302X UR - http://hdl.handle.net/20.500.12105/7251 AB - Several amino acid changes have been previously implicated in adaptation of avian influenza viruses to human hosts, among them the D701N change in the PB2 polymerase subunit that also is the main determinant of avian virus pathogenesis in animal... LA - eng PB - Frontiers Media KW - D701N mutation KW - PB2 subunit KW - Adaptation of avian viruses KW - Influenza virus KW - Pathogenicity TI - Identification of Rare PB2-D701N Mutation from a Patient with Severe Influenza: Contribution of the PB2-D701N Mutation to the Pathogenicity of Human Influenza TY - research article ER -