TY - JOUR AU - Rodriguez-Acebes, Sara AU - Mouron, Silvana Andrea AU - Mendez, Juan PY - 2018 DO - 10.1074/jbc.RA118.003740 SN - 0021-9258 UR - http://hdl.handle.net/20.500.12105/8366 AB - In growing cells, DNA replication precedes mitotic cell division to transmit genetic information to the next generation. The slowing or stalling of DNA replication forks at natural or exogenous obstacles causes "replicative stress" that promotes... LA - eng PB - American Society for Biochemistry and Molecular Biology (ASBMB) KW - DNA polymerase KW - DNA primase KW - DNA replication KW - Cell division cycle 7-related protein kinase (Cdc7) KW - Fork speed KW - Molecular biology KW - Replication origin KW - Replicative stress KW - Stretched DNA fibers KW - Aphidicolin KW - Cell Cycle Proteins KW - Cellular Senescence KW - DNA KW - DNA Repair KW - DNA Replication KW - HeLa Cells KW - Humans KW - Protein-Serine-Threonine Kinases KW - Replication Origin TI - Uncoupling fork speed and origin activity to identify the primary cause of replicative stress phenotypes TY - journal article ER -