TY - JOUR AU - Jimenez, Lucia AU - Amenabar, Carlos AU - Mayoral-Varo, Victor AU - Mackenzie, Thomas A AU - Ramos, Maria C AU - Silva, Andreia AU - Calissi, Giampaolo AU - Grenho, Inês AU - Blanco-Aparicio, Carmen AU - Pastor Fernandez, Joaquin AU - Megías, Diego AU - Ferreira, Bibiana I AU - Link, Wolfgang PY - 2022 DO - 10.3390/molecules27175414 UR - http://hdl.handle.net/20.500.12105/18895 AB - Forkhead box O (FOXO) proteins are transcription factors involved in cancer and aging and their pharmacological manipulation could be beneficial for the treatment of cancer and healthy aging. FOXO proteins are mainly regulated by post-translational... LA - eng PB - Multidisciplinary Digital Publishing Institute (MDPI) KW - Forkhead Transcription Factors KW - TOR Serine-Threonine Kinases KW - Forkhead Box Protein O3 KW - Mechanistic Target of Rapamycin Complex 1 KW - Mechanistic Target of Rapamycin Complex 2 KW - Phosphatidylinositol 3-Kinases KW - Proto-Oncogene Proteins c-akt TI - mTORC2 Is the Major Second Layer Kinase Negatively Regulating FOXO3 Activity. TY - journal article ER -