TY  - GEN
AU  - Guerra, Carmen
AU  - Mijimolle, Nieves
AU  - Dhawahir, Alma
AU  - Dubus, Pierre
AU  - Barradas, Marta
AU  - Serrano, Manuel
AU  - Campuzano, Victoria
AU  - Barbacid, Mariano
PY  - 2003
DO  - 10.1016/s1535-6108(03)00191-0
SN  - 1535-6108
UR  - https://hdl.handle.net/20.500.12105/23091
AB  - We have targeted a K-ras allele in mouse embryonic stem (ES) cells to express a K-Ras(V12) oncoprotein along with a marker protein (beta-geo) from a single bicistronic transcript. Expression of this oncogenic allele requires removal of a knocked in...
LA  - eng
PB  - Cell Press
KW  - Cell Transformation, Neoplastic
KW  - Protein Serine-Threonine Kinases
KW  - Animals
KW  - Cell Division
KW  - Cell Line, Transformed
KW  - Cellular Senescence
KW  - Chromosome Aberrations
KW  - Cyclin-Dependent Kinase Inhibitor p16
KW  - Fibroblasts
KW  - Gene Targeting
KW  - Genes, ras
KW  - Genetic Vectors
KW  - MAP Kinase Signaling System
KW  - Mice
KW  - Mice, Transgenic
KW  - Neoplasms
KW  - Oncogene Protein p21(ras)
KW  - Proto-Oncogene Proteins
KW  - Proto-Oncogene Proteins c-akt
KW  - Reverse Transcriptase Polymerase Chain Reaction
KW  - Stem Cells
KW  - Survival Rate
KW  - Tumor Suppressor Protein p14ARF
KW  - Tumor Suppressor Protein p53
TI  - Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context.
TY  - research article
ER  -