TY  - GEN
AU  - Prieto, Ignacio
AU  - Zambrano, Alberto
AU  - Laso, Javier
AU  - Aranda, Ana
AU  - Samper, Enrique
AU  - Monsalve, María
PY  - 2019
DO  - 10.1016/j.freeradbiomed.2019.04.015
UR  - http://hdl.handle.net/20.500.12105/12946
AB  - Aims: Oxidative stress is known to induce early replicative senescence. Senescence has been proposed to work as a barrier to immortalization and tumor development. Here, we aimed to evaluate the impact of the loss of peroxisome proliferator activated...
LA  - eng
PB  - Elsevier
KW  - Immortalization
KW  - Mitochondria
KW  - Oxidative stress
KW  - PGC-1α
KW  - Senescence
KW  - DNA Repair
KW  - Animals
KW  - Biomarkers
KW  - Cell Proliferation
KW  - Cellular Senescence
KW  - Cyclin-Dependent Kinase Inhibitor p16
KW  - Cyclin-Dependent Kinase Inhibitor p19
KW  - DNA
KW  - DNA Breaks, Double-Stranded
KW  - Embryo, Mammalian
KW  - Fibroblasts
KW  - Gamma Rays
KW  - Gene Expression Regulation
KW  - Mice
KW  - Mice, Knockout
KW  - Mitochondria
KW  - Oxidative Stress
KW  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
KW  - Phosphorylation
KW  - Reactive Oxygen Species
KW  - Tumor Suppressor Protein p53
KW  - Beta-Galactosidase
TI  - Early induction of senescence and immortalization in PGC-1α-deficient mouse embryonic fibroblasts
TY  - research article
ER  -