TY - GEN AU - Gonzalez-Freire, Marta AU - Moore, A. Zenobia AU - Peterson, Charlotte A AU - Kosmac, Kate AU - McDermott, Mary M AU - Sufit, Robert L AU - Guralnik, Jack M AU - Polonsky, Tamar AU - Tian, Lu AU - Kibbe, Melina R AU - Criqui, Michael H AU - Li, Lingyu AU - Leeuwenburgh, Christian AU - Ferrucci, Luigi PY - 2020 DO - 10.1161/JAHA.119.015197 SN - 2047-9980 UR - https://hdl.handle.net/20.500.12105/23044 AB - Background Patients with peripheral artery disease (PAD) undergo frequent episodes of ischemia-reperfusion in lower extremity muscles that may negatively affect mitochondrial health and are associated with impaired mobility. We hypothesized that... LA - eng PB - Wiley KW - Ankle brachial index KW - D-loop KW - Heteroplasmy KW - mtDNA KW - mtDNA copy number KW - Peripheral artery disease KW - Aged KW - Randomized Controlled Trials as Topic KW - Case-Control Studies KW - Muscle, Skeletal KW - Humans KW - Leg KW - Ischemia KW - Mitochondria, Muscle KW - Middle Aged KW - Cross-Sectional Studies KW - DNA, Mitochondrial KW - Male KW - Severity of Illness Index KW - Heteroplasmy KW - Female KW - Walking KW - Peripheral Arterial Disease KW - Mobility Limitation TI - Associations of Peripheral Artery Disease With Calf Skeletal Muscle Mitochondrial DNA Heteroplasmy TY - research article ER -