TY  - JOUR
AU  - Sedic, Maja
AU  - Skibinski, Adam
AU  - Brown, Nelson
AU  - Gallardo, Mercedes
AU  - Mulligan, Peter
AU  - Martinez Rodriguez, Paula
AU  - Keller, Patricia J
AU  - Glover, Eugene
AU  - Richardson, Andrea L
AU  - Cowan, Janet
AU  - Toland, Amanda E
AU  - Ravichandran, Krithika
AU  - Riethman, Harold
AU  - Naber, Stephen P
AU  - Näär, Anders M
AU  - Blasco, MA
AU  - Hinds, Philip W
AU  - Kuperwasser, Charlotte
PY  - 2015
DO  - 10.1038/ncomms8505
SN  - 2041-1723
UR  - http://hdl.handle.net/20.500.12105/10004
AB  - Although BRCA1 function is essential for maintaining genomic integrity in all cell types, it is unclear why increased risk of cancer in individuals harbouring deleterious mutations in BRCA1 is restricted to only a select few tissues. Here we show that...
LA  - eng
PB  - Nature Publishing Group
KW  - Cellular Senescence
KW  - DNA Damage
KW  - Epithelial Cells
KW  - Genomic Instability
KW  - Heterozygote
KW  - Humans
KW  - Mammary Glands, Human
KW  - Mutation
KW  - Retinoblastoma Protein
KW  - Sirtuin 1
KW  - Telomere Shortening
KW  - Tumor Suppressor Protein p53
KW  - Genes, BRCA1
KW  - Haploinsufficiency
TI  - Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence
TY  - journal article
ER  -