TY  - GEN
AU  - Meghadri, Sri Harsha
AU  - Martinez-Delgado, Beatriz
AU  - Ostermann, Lena
AU  - Gomez-Mariano, Gema Maria
AU  - Perez-Luz, Sara
AU  - Tumpara, Srinu
AU  - Wrenger, Sabine
AU  - DeLuca, David S
AU  - Maus, Ulrich A
AU  - Welte, Tobias
AU  - Janciauskiene, Sabina
PY  - 2022
DO  - 10.3390/ijms231810425
UR  - http://hdl.handle.net/20.500.12105/15879
AB  - The SERPINA1 gene encodes alpha1-antitrypsin (AAT), an acute phase glycoprotein and serine protease inhibitor that is mainly (80-90%) produced in the liver. Point mutations in the SERPINA1 gene can lead to the misfolding, intracellular accumulation,...
LA  - eng
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
KW  - Liver
KW  - SERPINA
KW  - Mice
KW  - Gene knockout
KW  - RNA sequencing
KW  - Transcriptomics
KW  - Metabolism
KW  - Single-cell
KW  - Alpha1-antitrypsin
KW  - Protein misfolding
KW  - Data analysis
KW  - alpha 1-Antitrypsin Deficiency
KW  - Animals
KW  - Cholesterol
KW  - Gene Expression
KW  - Humans
TI  - Loss of Serpina1 in Mice Leads to Altered Gene Expression in Inflammatory and Metabolic Pathways
TY  - research article
ER  -