TY - JOUR AU - Murga, Matilde AU - Lecona, Emilio AU - Kamileri, Irene AU - Díaz, Marcos AU - Lugli, Natalia AU - Sotiriou, Sotirios K AU - Anton, Marta E AU - Mendez, Juan AU - Halazonetis, Thanos D AU - Fernandez-Capetillo, Oscar PY - 2016 DO - 10.1016/j.molcel.2016.07.007 SN - 10972765 UR - http://hdl.handle.net/20.500.12105/8527 AB - The Pold3 gene encodes a subunit of the Polδ DNA polymerase complex. Pold3 orthologs are not essential in Saccharomyces cerevisiae or chicken DT40 cells, but the Schizosaccharomyces pombe ortholog is essential. POLD3 also has a specialized role in the... LA - eng PB - Cell Press KW - Animals KW - B-Lymphocytes KW - Brain KW - Cell Death KW - Checkpoint Kinase 1 KW - DNA Damage KW - DNA Polymerase III KW - Gene Expression Regulation, Developmental KW - Histones KW - Homozygote KW - Hydrocephalus KW - Longevity KW - Lung KW - Mice KW - Mice, Knockout KW - Phosphorylation KW - Survival Analysis KW - DNA Replication KW - Haploinsufficiency TI - POLD3 Is Haploinsufficient for DNA Replication in Mice TY - journal article ER -