TY - THES AU - Menchero, Sergio A3 - Manzanares, Miguel PY - 2019 DO - 10.4321/repisalud.7169 UR - http://hdl.handle.net/20.500.12105/7169 AB - A central question in developmental biology is how a single cell, the zygote, divides and differentiates to generate all the specialised cells that will build a whole organism. The zygote has totipotent capacity, which means that it is able to give... LA - eng KW - preimplantation embryo KW - notch KW - Cdx2 KW - morula KW - trophectoderm TI - Onset of cell differentiation and first lineages decisions in the mouse embryo through the Notch pathway M3 - doctoral thesis ER -