TY  - GEN
AU  - Zecchini, Vincent
AU  - Paupe, Vincent
AU  - Herranz-Montoya, Irene
AU  - Janssen, Joëlle
AU  - Wortel, Inge M N
AU  - Morris, Jordan L
AU  - Ferguson, Ashley
AU  - Chowdury, Suvagata Roy
AU  - Segarra-Mondejar, Marc
AU  - Costa, Ana SH
AU  - Pereira, Gonçalo C
AU  - Tronci, Laura
AU  - Young, Timothy
AU  - Nikitopoulou, Efterpi
AU  - Yang, Ming
AU  - Bihary, Dóra
AU  - Caicci, Federico
AU  - Nagashima, Shun
AU  - Speed, Alyson
AU  - Bokea, Kalliopi
AU  - Baig, Zara
AU  - Samarajiwa, Shamith
AU  - Tran, Maxine
AU  - Mitchell, Thomas
AU  - Johnson, Mark
AU  - Prudent, Julien
AU  - Frezza, Christian
PY  - 2023
DO  - 10.1038/s41586-023-05770-w
UR  - https://hdl.handle.net/20.500.12105/23110
AB  - Mutations in fumarate hydratase (FH) cause hereditary leiomyomatosis and renal cell carcinoma1. Loss of FH in the kidney elicits several oncogenic signalling cascades through the accumulation of the oncometabolite fumarate2. However, although the...
LA  - eng
PB  - Nature Publishing Group
KW  - DNA, Mitochondrial
KW  - Fumarates
KW  - Immunity, Innate
KW  - Mitochondria
KW  - Animals
KW  - Mice
KW  - Fumarate Hydratase
KW  - Kidney
KW  - Cytosol
TI  - Fumarate induces vesicular release of mtDNA to drive innate immunity
TY  - research article
ER  -