TY - JOUR AU - Compte, Marta AU - Harwood, Seandean Lykke AU - Muñoz, Ines G AU - Navarro, Rocio AU - Zonca, Manuela AU - Perez-Chacon, Gema AU - Erce-Llamazares, Ainhoa AU - Merino, Nekane AU - Tapia-Galisteo, Antonio AU - Cuesta, Angel M AU - Mikkelsen, Kasper AU - Caleiras, Eduardo AU - Nuñez-Prado, Natalia AU - Aznar, M Angela AU - Lykkemark, Simon AU - Martinez Torrecuadrada, Jorge Luis AU - Melero, Ignacio AU - Blanco, Francisco J AU - Bernardino de la Serna, Jorge AU - Zapata, Juan M AU - Sanz, Laura AU - Álvarez-Vallina, Luis PY - 2018 DO - 10.1038/s41467-018-07195-w SN - 2041-1723 UR - http://hdl.handle.net/20.500.12105/6702 AB - The costimulation of immune cells using first-generation anti-4-1BB monoclonal antibodies (mAbs) has demonstrated anti-tumor activity in human trials. Further clinical development, however, is restricted by significant off-tumor toxicities associated... LA - eng PB - Nature Publishing Group TI - A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity TY - journal article ER -