TY  - JOUR
AU  - Rodríguez-Arce, Irene
AU  - Martí, Sara
AU  - Euba, Begoña
AU  - Fernández-Calvet, Ariadna
AU  - Moleres, Javier
AU  - López-López, Nahikari
AU  - Barberán, Montserrat
AU  - Ramos-Vivas, José
AU  - Tubau, Fe
AU  - Losa, Carmen
AU  - Ardanuy, Carmen
AU  - Leiva, José
AU  - Yuste, Jose Enrique
AU  - Garmendia, Junkal
PY  - 2017
DO  - 10.3389/fcimb.2017.00266
SN  - 2235-2988
UR  - http://hdl.handle.net/20.500.12105/7332
AB  - Antibacterial treatment with cotrimoxazol (TxS), a combination of trimethoprim and sulfamethoxazole, generates resistance by, among others, acquisition of thymidine auxotrophy associated with mutations in the thymidylate synthase gene thyA, which can...
LA  - eng
PB  - Frontiers Media
KW  - Haemophilus influenzae
KW  - Airway infection
KW  - Antibiotic resistance
KW  - Bacterial morphology
KW  - Thymidine auxotrophy
KW  - Thymidine uptake
KW  - Thymidylate synthase
KW  - A549 Cells
KW  - Animals
KW  - Anti-Bacterial Agents
KW  - Bacterial Proteins
KW  - Cell Line, Tumor
KW  - DNA, Bacterial
KW  - Drug Resistance, Microbial
KW  - Female
KW  - Genes, Bacterial
KW  - Haemophilus Infections
KW  - Haemophilus influenzae
KW  - Host-Pathogen Interactions
KW  - Humans
KW  - Interleukin-8
KW  - Lung
KW  - Mice
KW  - Microscopy, Electron, Transmission
KW  - Mutation
KW  - Respiratory Tract Infections
KW  - Spain
KW  - Sulfamethoxazole
KW  - Thymidine
KW  - Thymidylate Synthase
KW  - Trimethoprim
KW  - Trimethoprim, Sulfamethoxazole Drug Combination
KW  - Virulence
TI  - Inactivation of the Thymidylate Synthase thyA in Non-typeable Haemophilus influenzae Modulates Antibiotic Resistance and Has a Strong Impact on Its Interplay with the Host Airways
TY  - journal article
ER  -