TY  - GEN
AU  - Mellado, Emilia
AU  - Garcia-Effron, Guillermo
AU  - Alcazar-Fuoli, Laura
AU  - Cuenca-Estrella, Manuel
AU  - Rodriguez-Tudela, Juan Luis
PY  - 2004
DO  - 10.1128/AAC.48.7.2747-2750.2004
SN  - 0066-4804
UR  - http://hdl.handle.net/20.500.12105/8260
AB  - Five clinical isolates of Aspergillus fumigatus that exhibited similar patterns of reduced susceptibility to itraconazole and other triazole drugs were analyzed. Sequence analysis of genes (cyp51A and cyp51B) encoding the 14alpha-sterol demethylases...
LA  - eng
PB  - American Society for Microbiology (ASM)
KW  - Alleles
KW  - Amino Acid Sequence
KW  - Amino Acid Substitution
KW  - Antifungal Agents
KW  - Aspergillus fumigatus
KW  - Azoles
KW  - Cytochrome P-450 Enzyme System
KW  - Drug Resistance, Fungal
KW  - Fungal Proteins
KW  - Methionine
KW  - Microbial Sensitivity Tests
KW  - Molecular Sequence Data
KW  - Mutation
KW  - Reverse Transcriptase Polymerase Chain Reaction
TI  - Substitutions at methionine 220 in the 14alpha-sterol demethylase (Cyp51A) of Aspergillus fumigatus are responsible for resistance in vitro to azole antifungal drugs
TY  - research article
ER  -