2024-03-28T23:21:05Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/96862022-10-25T07:34:40Zcom_20.500.12105_2109com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2110
Repisalud
author
Calero, Miguel
author
Gómez-Ramos, Alberto
author
Calero, Olga
author
Soriano, Eduardo
author
Avila, Jesús
author
Medina, Miguel
funder
Instituto de Salud Carlos III
2020-04-22T16:09:05Z
2020-04-22T16:09:05Z
2015
Front Cell Neurosci. 2015 Apr 9;9:138.
1662-5102
http://hdl.handle.net/20.500.12105/9686
25914626
10.3389/fncel.2015.00138
Frontiers in cellular neuroscience
Familial Alzheimer's disease (AD), mostly associated with early onset, is caused by mutations in three genes (APP, PSEN1, and PSEN2) involved in the production of the amyloid β peptide. In contrast, the molecular mechanisms that trigger the most common late onset sporadic AD remain largely unknown. With the implementation of an increasing number of case-control studies and the upcoming of large-scale genome-wide association studies there is a mounting list of genetic risk factors associated with common genetic variants that have been associated with sporadic AD. Besides apolipoprotein E, that presents a strong association with the disease (OR∼4), the rest of these genes have moderate or low degrees of association, with OR ranging from 0.88 to 1.23. Taking together, these genes may account only for a fraction of the attributable AD risk and therefore, rare variants and epistastic gene interactions should be taken into account in order to get the full picture of the genetic risks associated with AD. Here, we review recent whole-exome studies looking for rare variants, somatic brain mutations with a strong association to the disease, and several studies dealing with epistasis as additional mechanisms conferring genetic susceptibility to AD. Altogether, recent evidence underlines the importance of defining molecular and genetic pathways, and networks rather than the contribution of specific genes.
eng
Alzheimer
GWAS
Epistasis
Exome
Neurodegeneration
Rare variants
Risk factors
Somatic mutations
Additional mechanisms conferring genetic susceptibility to Alzheimer's disease
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/9686/1/AdditionalMechanismsConferringGenetic_2015.pdf
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https://repisalud.isciii.es/bitstream/20.500.12105/9686/5/AdditionalMechanismsConferringGenetic_2015.pdf.txt
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AdditionalMechanismsConferringGenetic_2015.pdf.txt