2024-03-29T11:45:39Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/96852023-10-13T07:20:55Zcom_20.500.12105_2145com_20.500.12105_2051com_20.500.12105_2144col_20.500.12105_2146
Repisalud
author
Lim, R
author
Sugino, T
author
Nolte, H
author
Andrade, J
author
Zimmermann, B
author
Shi, C
author
Doddaballapur, A
author
Ong, Y T
author
Wilhelm, K
author
Fasse, J W D
author
Ernst, A
author
Kaulich, M
author
Husnjak, K
author
Boettger, T
author
Guenther, S
author
Braun, T
author
Krüger, M
author
Benedito, Rui
author
Dikic, I
author
Potente, M
funder
Max Planck Society
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Deutsche Forschungsgemeinschaft (Alemania)
funder
German Centre for Cardiovascular Research
funder
European Molecular Biology Organization
2020-04-22T16:00:30Z
2020-04-22T16:00:30Z
2019-04
Science. 2019; 364(6436):188-193
http://hdl.handle.net/20.500.12105/9685
30975888
10.1126/science.aat0778
1095-9203
Science (New York, N.Y.)
Notch signaling is a core patterning module for vascular morphogenesis that codetermines the sprouting behavior of endothelial cells (ECs). Tight quantitative and temporal control of Notch activity is essential for vascular development, yet the details of Notch regulation in ECs are incompletely understood. We found that ubiquitin-specific peptidase 10 (USP10) interacted with the NOTCH1 intracellular domain (NICD1) to slow the ubiquitin-dependent turnover of this short-lived form of the activated NOTCH1 receptor. Accordingly, inactivation of USP10 reduced NICD1 abundance and stability and diminished Notch-induced target gene expression in ECs. In mice, the loss of endothelial Usp10 increased vessel sprouting and partially restored the patterning defects caused by ectopic expression of NICD1. Thus, USP10 functions as an NICD1 deubiquitinase that fine-tunes endothelial Notch responses during angiogenic sprouting.
eng
Deubiquitinase USP10 regulates Notch signaling in the endothelium
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/9685/1/DeubiquitinaseUSP10RegulatesNotch_2019.pdf
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DeubiquitinaseUSP10RegulatesNotch_2019.pdf
URL
https://repisalud.isciii.es/bitstream/20.500.12105/9685/3/DeubiquitinaseUSP10RegulatesNotch_2019.pdf.txt
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MD5
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DeubiquitinaseUSP10RegulatesNotch_2019.pdf.txt